5701 - 5750 of 5832 Results
Title
Year
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OPENTitle: Mutant LRRK2R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's diseaseJournal Name: Nature NeurosciencePublisher: Springer Science and Business Media LLCVol: 12Issue #: 7Start Page: 826End Page: 828Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/nn.2349Best OA location URL: https://europepmc.org/articles/pmc2845930?pdf=renderCitation Count: 505
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OPENTitle: Striatal Overexpression of ΔJunD Resets L-DOPA-Induced Dyskinesia in a Primate Model of Parkinson DiseaseJournal Name: Biological PsychiatryPublisher: Elsevier BVVol: 66Issue #: 6Start Page: 554End Page: 561Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.biopsych.2009.04.005Best OA location URL: https://europepmc.org/articles/pmc2825375?pdf=renderCitation Count: 89
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OPENTitle: Synthesis and Evaluation of a Series of Heterobiarylamides That Are Centrally Penetrant Metabotropic Glutamate Receptor 4 (mGluR4) Positive Allosteric Modulators (PAMs)Journal Name: Journal of Medicinal ChemistryPublisher: American Chemical Society (ACS)Vol: 52Issue #: 14Start Page: 4115End Page: 4118Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1021/jm9005065Best OA location URL: https://europepmc.org/articles/pmc2765192?pdf=renderCitation Count: 78
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OPENTitle: Subventricular zone neural progenitors from rapid brain autopsies of elderly subjects with and without neurodegenerative diseaseJournal Name: Journal of Comparative NeurologyPublisher: WileyVol: 515Issue #: 3Start Page: 269End Page: 294Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/cne.22040Best OA location URL: https://europepmc.org/articles/pmc2757160?pdf=renderCitation Count: 52
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OPENTitle: A role for a novel protein, nucleolin, in Parkinson's diseaseJournal Name: Neuroscience LettersPublisher: Elsevier BVVol: 459Issue #: 1Start Page: 11End Page: 15Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neulet.2009.04.060Best OA location URL: https://europepmc.org/articles/pmc2771225?pdf=renderCitation Count: 43
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OPENTitle: Delayed gastric emptying and enteric nervous system dysfunction in the rotenone model of Parkinson's diseaseJournal Name: Experimental NeurologyPublisher: Elsevier BVVol: 218Issue #: 1Start Page: 154End Page: 161Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.expneurol.2009.04.023Best OA location URL: https://europepmc.org/articles/pmc2696567?pdf=renderCitation Count: 156
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OPENTitle: Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunctionJournal Name: Acta NeuropathologicaPublisher: Springer Science and Business Media LLCVol: 117Issue #: 6Start Page: 613End Page: 634Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/s00401-009-0538-8Best OA location URL: https://europepmc.org/articles/pmc2757320?pdf=renderCitation Count: 582
- Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells2009OPENTitle: Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cellsJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 106Issue #: 18Start Page: 7613End Page: 7618Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.0902396106Best OA location URL: https://europepmc.org/articles/pmc2671325?pdf=renderCitation Count: 216
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OPENTitle: SNCA variants are associated with increased risk for multiple system atrophyJournal Name: Annals of NeurologyPublisher: WileyVol: 65Issue #: 5Start Page: 610End Page: 614Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/ana.21685Best OA location URL: https://europepmc.org/articles/pmc3520128?pdf=renderCitation Count: 268
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OPENTitle: Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppressionJournal Name: Neural DevelopmentPublisher: Springer Science and Business Media LLCVol: 4Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/1749-8104-4-11Best OA location URL: https://neuraldevelopment.biomedcentral.com/counter/pdf/10.1186/1749-8104-4-11Citation Count: 34
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OPENTitle: Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's diseaseJournal Name: BrainPublisher: Oxford University Press (OUP)Vol: 132Issue #: 7Start Page: 1783End Page: 1794Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1093/brain/awp044Best OA location URL: https://academic.oup.com/brain/article-pdf/132/7/1783/13734818/awp044.pdfCitation Count: 629
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OPENTitle: Validity and Reliability of an Occupational Exposure Questionnaire for Parkinsonism in WeldersJournal Name: Journal of Occupational and Environmental HygienePublisher: Informa UK LimitedVol: 6Issue #: 6Start Page: 324End Page: 331Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1080/15459620902836856Best OA location URL: https://europepmc.org/articles/pmc2879629?pdf=renderCitation Count: 31
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OPENTitle: A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's diseaseJournal Name: Neurobiology of DiseasePublisher: Elsevier BVVol: 34Issue #: 3Start Page: 417End Page: 431Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.nbd.2009.02.009Best OA location URL: https://europepmc.org/articles/pmc2784936?pdf=renderCitation Count: 183
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OPENTitle: Embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non‐human primate after overexpression of GDNFJournal Name: Journal of Comparative NeurologyPublisher: WileyVol: 515Issue #: 1Start Page: 31End Page: 40Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/cne.22028Best OA location URL: https://europepmc.org/articles/pmc2881694?pdf=renderCitation Count: 40
- Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation2009OPENTitle: Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradationJournal Name: Journal of Clinical InvestigationPublisher: American Society for Clinical InvestigationVol: 119Issue #: 3Start Page: 650End Page: 660Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1172/jci37617Best OA location URL: http://www.jci.org/articles/view/37617/files/pdfCitation Count: 371
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OPENTitle: Interaction of the amyloid imaging tracer FDDNP with hallmark Alzheimer’s disease pathologiesJournal Name: Journal of NeurochemistryPublisher: WileyVol: 109Issue #: 2Start Page: 623End Page: 630Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1111/j.1471-4159.2009.05996.xBest OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1471-4159.2009.05996.xCitation Count: 134
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OPENTitle: Long-term Transgene Expression in the Central Nervous System Using DNA NanoparticlesJournal Name: Molecular TherapyPublisher: Elsevier BVVol: 17Issue #: 4Start Page: 641End Page: 650Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1038/mt.2009.2Best OA location URL: http://www.cell.com/article/S152500161631557X/pdfCitation Count: 77
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OPENTitle: Evaluation of D2 and D3 dopamine receptor selective compounds on l-dopa-dependent abnormal involuntary movements in ratsJournal Name: NeuropharmacologyPublisher: Elsevier BVVol: 56Issue #: 6-7Start Page: 956End Page: 969Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neuropharm.2009.01.019Best OA location URL: https://europepmc.org/articles/pmc4106465?pdf=renderCitation Count: 53
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OPENTitle: Evaluation of the D3 dopamine receptor selective antagonist PG01037 on l-dopa-dependent abnormal involuntary movements in ratsJournal Name: NeuropharmacologyPublisher: Elsevier BVVol: 56Issue #: 6-7Start Page: 944End Page: 955Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neuropharm.2009.01.020Best OA location URL: https://europepmc.org/articles/pmc3820009?pdf=renderCitation Count: 46
- Expression and localization of lactotransferrin messenger RNA in the cortex of Alzheimer's disease2009OPENTitle: Expression and localization of lactotransferrin messenger RNA in the cortex of Alzheimer's diseaseJournal Name: Neuroscience LettersPublisher: Elsevier BVVol: 452Issue #: 3Start Page: 277End Page: 280Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neulet.2009.01.071Best OA location URL: https://europepmc.org/articles/pmc2667624?pdf=renderCitation Count: 33
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OPENTitle: α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicityJournal Name: Nature GeneticsPublisher: Springer Science and Business Media LLCVol: 41Issue #: 3Start Page: 308End Page: 315Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/ng.300Best OA location URL: https://europepmc.org/articles/pmc2683786?pdf=renderCitation Count: 527
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OPENTitle: Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neuronsJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 106Issue #: 7Start Page: 2429End Page: 2434Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.0810996106Best OA location URL: https://europepmc.org/articles/pmc2650173?pdf=renderCitation Count: 136
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OPENTitle: FGF20 and Parkinson's disease: No evidence of association or pathogenicity via α‐synuclein expressionJournal Name: Movement DisordersPublisher: WileyVol: 24Issue #: 3Start Page: 455End Page: 459Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.22442Best OA location URL: https://europepmc.org/articles/pmc2875476?pdf=renderCitation Count: 44
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OPENTitle: Funding of Parkinson research from industry and US federal and foundation sourcesJournal Name: Movement DisordersPublisher: WileyVol: 24Issue #: 5Start Page: 731End Page: 737Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.22446Best OA location URL: http://ecommons.library.cornell.edu/bitstream/1813/15097/2/Nicholson 09 pub 02.pdfCitation Count: 6
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OPENTitle: Future of cell and gene therapies for Parkinson's diseaseJournal Name: Annals of NeurologyPublisher: WileyVol: 64Issue #: S2Start Page: S122End Page: S138Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/ana.21473Best OA location URL: https://europepmc.org/articles/pmc3982797?pdf=renderCitation Count: 53
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OPENTitle: Alzheimer Research Forum Live Discussion: Mice on Trial? Issues in the Design of Drug StudiesJournal Name: Journal of Alzheimer's DiseasePublisher: SAGE PublicationsVol: 16Issue #: 1Start Page: 197End Page: 205Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.3233/jad-2009-0961Best OA location URL: https://content.iospress.com:443/download/journal-of-alzheimers-disease/jad00961?id=journal-of-alzheimers-disease%2Fjad00961Citation Count: 1
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OPENTitle: Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathwayJournal Name: Neurobiology of DiseasePublisher: Elsevier BVVol: 34Issue #: 1Start Page: 95End Page: 106Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.nbd.2008.12.007Best OA location URL: https://europepmc.org/articles/pmc2720310?pdf=renderCitation Count: 216
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OPENTitle: Differentiation of Neural Precursors and Dopaminergic Neurons from Human Embryonic Stem CellsJournal Name: Methods in Molecular BiologyPublisher: Humana PressVol:Issue #:Start Page: 355End Page: 366Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/978-1-60761-369-5_19Best OA location URL: https://europepmc.org/articles/pmc2948208?pdf=renderCitation Count: 97
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OPENTitle: Linkage of cDNA expression profiles of mesencephalic dopaminergic neurons to a genome-wide in situ hybridization databaseJournal Name: Molecular NeurodegenerationPublisher: Springer Science and Business Media LLCVol: 4Issue #: 1Start Page: 6End Page: 6Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/1750-1326-4-6Best OA location URL: https://molecularneurodegeneration.biomedcentral.com/counter/pdf/10.1186/1750-1326-4-6Citation Count: 10
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OPENTitle: Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-leadJournal Name: Bioorganic & Medicinal Chemistry LettersPublisher: Elsevier BVVol: 19Issue #: 3Start Page: 962End Page: 966Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.bmcl.2008.11.104Best OA location URL: https://europepmc.org/articles/pmc3787871?pdf=renderCitation Count: 55
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OPENTitle: Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson diseaseJournal Name: Journal of Clinical InvestigationPublisher: American Society for Clinical InvestigationVol:Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1172/jci36470Best OA location URL: http://www.jci.org/articles/view/36470/files/pdfCitation Count: 1085
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OPENTitle: Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicityJournal Name: Molecular BrainPublisher: Springer Science and Business Media LLCVol: 1Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/1756-6606-1-17Best OA location URL: https://molecularbrain.biomedcentral.com/counter/pdf/10.1186/1756-6606-1-17Citation Count: 241
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OPENTitle: Structural insights into phenylethanolamines high-affinity binding site in NR2B from binding and molecular modeling studiesJournal Name: Molecular BrainPublisher: Springer Science and Business Media LLCVol: 1Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/1756-6606-1-16Best OA location URL: https://molecularbrain.biomedcentral.com/counter/pdf/10.1186/1756-6606-1-16Citation Count: 23
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OPENTitle: Ephrin‐A5 regulates the formation of the ascending midbrain dopaminergic pathwaysJournal Name: Developmental NeurobiologyPublisher: WileyVol: 69Issue #: 1Start Page: 36End Page: 46Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/dneu.20685Best OA location URL: https://europepmc.org/articles/pmc4026181?pdf=renderCitation Count: 39
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OPENTitle: Olfactory bulb α-synucleinopathy has high specificity and sensitivity for Lewy body disordersJournal Name: Acta NeuropathologicaPublisher: Springer Science and Business Media LLCVol: 117Issue #: 2Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/s00401-008-0450-7Best OA location URL: https://europepmc.org/articles/pmc2631085?pdf=renderCitation Count: 213
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OPENTitle: Stem cells in development of therapeutics for Parkinson's disease: A perspectiveJournal Name: Journal of Cellular BiochemistryPublisher: WileyVol: 105Issue #: 5Start Page: 1153End Page: 1160Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/jcb.21916Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcb.21916Citation Count: 15
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OPENTitle: Administration and Scoring Variance on the ADAS-CogJournal Name: Journal of Alzheimer's DiseasePublisher: SAGE PublicationsVol: 15Issue #: 3Start Page: 461End Page: 464Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.3233/jad-2008-15312Best OA location URL: https://europepmc.org/articles/pmc2727511?pdf=renderCitation Count: 73
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OPENTitle: Dietary Iron Intake and Risk of Parkinson's DiseaseJournal Name: American Journal of EpidemiologyPublisher: Oxford University Press (OUP)Vol: 168Issue #: 12Start Page: 1381End Page: 1388Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1093/aje/kwn273Best OA location URL: https://academic.oup.com/aje/article-pdf/168/12/1381/365552/kwn273.pdfCitation Count: 85
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OPENTitle: JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degenerationJournal Name: Journal of NeurochemistryPublisher: WileyVol: 107Issue #: 6Start Page: 1578End Page: 1588Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1111/j.1471-4159.2008.05713.xBest OA location URL: https://europepmc.org/articles/pmc2632584?pdf=renderCitation Count: 78
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OPENTitle: The Role of Lmx1a in the Differentiation of Human Embryonic Stem Cells into Midbrain Dopamine Neurons in Culture and After Transplantation into a Parkinson's Disease ModelJournal Name: Stem CellsPublisher: Oxford University Press (OUP)Vol: 27Issue #: 1Start Page: 220End Page: 229Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1634/stemcells.2008-0734Best OA location URL: https://academic.oup.com/stmcls/article-pdf/27/1/220/41946326/stmcls_27_1_220.pdfCitation Count: 78
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OPENTitle: Cost effectiveness of preventing falls and improving mobility in people with Parkinson disease: protocol for an economic evaluation alongside a clinical trialJournal Name: BMC GeriatricsPublisher: Springer Science and Business Media LLCVol: 8Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/1471-2318-8-23Best OA location URL: https://bmcgeriatr.biomedcentral.com/track/pdf/10.1186/1471-2318-8-23Citation Count: 31
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OPENTitle: Decreased expression of CD200 and CD200 receptor in Alzheimer's disease: A potential mechanism leading to chronic inflammationJournal Name: Experimental NeurologyPublisher: Elsevier BVVol: 215Issue #: 1Start Page: 5End Page: 19Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.expneurol.2008.09.003Best OA location URL: https://europepmc.org/articles/pmc2765462?pdf=renderCitation Count: 240
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OPENTitle: Genetic variation of Omi/HtrA2 and Parkinson's diseaseJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 14Issue #: 7Start Page: 539End Page: 543Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2008.08.003Best OA location URL: https://europepmc.org/articles/pmc2614082?pdf=renderCitation Count: 70
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OPENTitle: Proteomic identification of proteins in the human brain: Towards a more comprehensive understanding of neurodegenerative diseaseJournal Name: PROTEOMICS – Clinical ApplicationsPublisher: WileyVol: 2Issue #: 10-11Start Page: 1484End Page: 1497Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/prca.200800043Best OA location URL: https://europepmc.org/articles/pmc3142616?pdf=renderCitation Count: 27
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OPENTitle: Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulatorsJournal Name: Bioorganic & Medicinal Chemistry LettersPublisher: Elsevier BVVol: 18Issue #: 20Start Page: 5626End Page: 5630Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.bmcl.2008.08.087Best OA location URL: https://europepmc.org/articles/pmc3182458?pdf=renderCitation Count: 56
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OPENTitle: Hsp104 antagonizes α-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson diseaseJournal Name: Journal of Clinical InvestigationPublisher: American Society for Clinical InvestigationVol: 118Issue #: 9Start Page: 3087End Page: 3097Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1172/jci35781Best OA location URL: http://www.jci.org/articles/view/35781/files/pdfCitation Count: 186
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OPENTitle: Enantiomeric Propanolamines as selectiveN-Methyl-d-aspartate 2B Receptor AntagonistsJournal Name: Journal of Medicinal ChemistryPublisher: American Chemical Society (ACS)Vol: 51Issue #: 18Start Page: 5506End Page: 5521Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1021/jm8002153Best OA location URL: https://europepmc.org/articles/pmc3142473?pdf=renderCitation Count: 25
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OPENTitle: Generation of Stable Transgenic C. elegans Using MicroinjectionJournal Name: Journal of Visualized ExperimentsPublisher: MyJove CorporationVol:Issue #: 18Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.3791/833Best OA location URL: https://europepmc.org/articles/pmc3253564?pdf=renderCitation Count: 82
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OPENTitle: GATA transcription factors directly regulate the Parkinson's disease-linked gene α-synucleinJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 105Issue #: 31Start Page: 10907End Page: 10912Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.0802437105Best OA location URL: https://www.pnas.org/content/pnas/105/31/10907.full.pdfCitation Count: 251
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OPENTitle: UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicalsJournal Name: NaturePublisher: Springer Science and Business Media LLCVol: 454Issue #: 7206Start Page: 846End Page: 851Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/nature07181Best OA location URL: https://europepmc.org/articles/pmc4101536?pdf=renderCitation Count: 681