851 - 900 of 6557 Results
Title
Year
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OPENTitle: Reduced thalamic excitation to motor cortical pyramidal tract neurons in parkinsonismJournal Name: Science AdvancesPublisher: American Association for the Advancement of Science (AAAS)Vol: 9Issue #: 34Start Page: eadg3038End Page: eadg3038Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1126/sciadv.adg3038Best OA location URL: https://www.science.org/doi/pdf/10.1126/sciadv.adg3038?download=trueCitation Count: 21
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OPENTitle: BDNF rs6265 Variant Alters Outcomes with Levodopa in Early-Stage Parkinson's DiseaseJournal Name: NeurotherapeuticsPublisher: Elsevier BVVol: 17Issue #: 4Start Page: 1785End Page: 1795Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/s13311-020-00965-9Best OA location URL: https://link.springer.com/content/pdf/10.1007/s13311-020-00965-9.pdfCitation Count: 19
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OPENTitle: Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational studyJournal Name: The Lancet NeurologyPublisher: Elsevier BVVol: 20Issue #: 3Start Page: 203End Page: 212Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/s1474-4422(20)30449-xBest OA location URL: http://hdl.handle.net/2445/214932Citation Count: 331
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OPENTitle: Safety and efficacy of tilavonemab in progressive supranuclear palsy: a phase 2, randomised, placebo-controlled trialJournal Name: The Lancet NeurologyPublisher: Elsevier BVVol: 20Issue #: 3Start Page: 182End Page: 192Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/s1474-4422(20)30489-0Best OA location URL: http://www.thelancet.com/article/S1474442220304890/pdfCitation Count: 137
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OPENTitle: Prehospital scales in acute ischaemic stroke management – Authors' replyJournal Name: The Lancet NeurologyPublisher: Elsevier BVVol: 20Issue #: 7Start Page: 504End Page: 505Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/s1474-4422(21)00169-1Best OA location URL: https://pure.eur.nl/en/publications/25abb6f2-0472-4754-8580-97e2533ac37aCitation Count: 1
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OPENTitle: Description of a European memory clinic cohort undergoing amyloid‐PET: The AMYPAD Diagnostic and Patient Management StudyJournal Name: Alzheimer's & DementiaPublisher: WileyVol: 19Issue #: 3Start Page: 844End Page: 856Publication Date:Open Access(OA) Status: OPENLicense: cc-by-ncDOI - Digital Object Identifier: 10.1002/alz.12696Best OA location URL: https://pub.dzne.de/search?p=id:%22DZNE-2022-01312%22Citation Count: 17
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OPENTitle: Relationship of serum beta‐synuclein with blood biomarkers and brain atrophyJournal Name: Alzheimer's & DementiaPublisher: WileyVol: 19Issue #: 4Start Page: 1358End Page: 1371Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1002/alz.12790Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.12790Citation Count: 52
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OPENTitle: Blood RNA transcripts reveal similar and differential alterations in fundamental cellular processes in Alzheimer's disease and other neurodegenerative diseasesJournal Name: Alzheimer's & DementiaPublisher: WileyVol: 19Issue #: 6Start Page: 2618End Page: 2632Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/alz.12880Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/11633037Citation Count: 28
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OPENTitle: 146th Annual Meeting American Neurological AssociationJournal Name: Annals of NeurologyPublisher: WileyVol: 90Issue #: S27Start Page: S1End Page: S270Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/ana.26180Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ana.26180Citation Count: 17
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OPENTitle: Effect of glycine transporter 1 inhibition with bitopertin on parkinsonism and L-DOPA induced dyskinesia in the 6-OHDA-lesioned ratJournal Name: European Journal of PharmacologyPublisher: Elsevier BVVol: 929Issue #:Start Page: 175090End Page: 175090Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1016/j.ejphar.2022.175090Best OA location URL: https://doi.org/10.1016/j.ejphar.2022.175090Citation Count: 19
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OPENTitle: Classification based levodopamine response prediction in parkinson’s disorderJournal Name: Applied Artificial IntelligencePublisher: Informa UK LimitedVol: 35Issue #: 15Start Page: 1287End Page: 1303Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1080/08839514.2021.1975881Best OA location URL: https://www.tandfonline.com/doi/pdf/10.1080/08839514.2021.1975881?needAccess=trueCitation Count: 2
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OPENTitle: Progression of Self-Perceived Speech and Swallowing Impairment in Early Stage Parkinson's Disease: Longitudinal Analysis of the Unified Parkinson's Disease Rating ScaleJournal Name: Journal of Speech, Language, and Hearing ResearchPublisher: American Speech Language Hearing AssociationVol: 65Issue #: 1Start Page: 146End Page: 158Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1044/2021_jslhr-21-00216Best OA location URL: https://doi.org/10.1044/2021_jslhr-21-00216Citation Count: 15
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OPENTitle: Genetics of Parkinson’s disease in the Polish populationJournal Name: Neurologia i Neurochirurgia PolskaPublisher: VM Media SP. zo.o VM Group SKVol: 55Issue #: 3Start Page: 241End Page: 252Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.5603/pjnns.a2021.0013Best OA location URL: https://journals.viamedica.pl/neurologia_neurochirurgia_polska/article/download/PJNNS.a2021.0013/54764Citation Count: 20
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OPENTitle: Invited Speakers’ SessionJournal Name: Rinsho ShinkeigakuPublisher: Societas Neurologica JaponicaVol: 61Issue #: SupplementStart Page: S1End Page: S220Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.5692/clinicalneurol.61_supplement_s1Best OA location URL: https://www.jstage.jst.go.jp/article/clinicalneurol/61/Supplement/61_61_supplement_S1/_pdfCitation Count: 0
- Poster Session2022OPENTitle: Poster SessionJournal Name: Rinsho ShinkeigakuPublisher: Societas Neurologica JaponicaVol: 62Issue #: SupplementStart Page: S247End Page: S393Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.5692/clinicalneurol.62_supplement_s247Best OA location URL: https://www.jstage.jst.go.jp/article/clinicalneurol/62/Supplement/62_62_supplement_S247/_pdfCitation Count: 2
- Arousal characteristics in patients with Parkinson’s disease and isolated rapid eye movement sleep behavior disorder2021OPENTitle: Arousal characteristics in patients with Parkinson’s disease and isolated rapid eye movement sleep behavior disorderJournal Name: SleepPublisher: Oxford University Press (OUP)Vol: 44Issue #: 12Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1093/sleep/zsab167Citation Count: 12
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OPENTitle: Viral overexpression of human alpha-synuclein in mouse substantia nigra dopamine neurons results in hyperdopaminergia but no neurodegenerationJournal Name: Experimental NeurologyPublisher: Elsevier BVVol: 382Issue #:Start Page: 114959End Page: 114959Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1016/j.expneurol.2024.114959Best OA location URL: https://doi.org/10.1016/j.expneurol.2024.114959Citation Count: 8
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OPENTitle: Functional efficacy of the MAO-B inhibitor safinamide in murine substantia nigra pars compacta dopaminergic neurons in vitro: A comparative study with tranylcypromineJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 128Issue #:Start Page: 107158End Page: 107158Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1016/j.parkreldis.2024.107158Best OA location URL: https://www.prd-journal.com/article/S1353-8020(24)01170-2/pdfCitation Count: 3
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OPENTitle: The GBA variant E326K is associated with alpha-synuclein aggregation and lipid droplet accumulation in human cell linesJournal Name: Human Molecular GeneticsPublisher: Oxford University Press (OUP)Vol:Issue #:Start Page: 773End Page: 789Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1093/hmg/ddac233Best OA location URL: https://academic.oup.com/hmg/article-pdf/32/5/773/49283269/ddac233.pdfCitation Count: 13
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OPENTitle: 0345 Life Course Sleep Duration Trajectories and Risk and Age at Onset of Parkinson’s DiseaseJournal Name: SLEEPPublisher: Oxford University Press (OUP)Vol: 48Issue #: Supplement_1Start Page: A150End Page: A150Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1093/sleep/zsaf090.0345Best OA location URL: https://academic.oup.com/sleep/article-pdf/48/Supplement_1/A150/63222627/zsaf090.0345.pdfCitation Count: 0
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OPENTitle: Optimization of Lipophilic Metalloporphyrins Modifies Disease Outcomes in a Rat Model of ParkinsonismJournal Name: The Journal of Pharmacology and Experimental TherapeuticsPublisher: Elsevier BVVol: 377Issue #: 1Start Page: 1End Page: 10Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1124/jpet.120.000229Best OA location URL: https://jpet.aspetjournals.org/content/jpet/377/1/1.full.pdfCitation Count: 6
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OPENTitle: Alpha‐Synuclein oligomerization and aggregation: All models are useful but only if we know what they modelJournal Name: Journal of NeurochemistryPublisher: WileyVol: 157Issue #: 4Start Page: 891End Page: 898Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1111/jnc.15275Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jnc.15275Citation Count: 7
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OPENTitle: fISHing with immunohistochemistry for housekeeping gene changes in Alzheimer’s disease using an automated quantitative analysis workflowJournal Name: Journal of NeurochemistryPublisher: WileyVol: 157Issue #: 4Start Page: 1270End Page: 1283Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1111/jnc.15283Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jnc.15283Citation Count: 7
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OPENTitle: Differentiation of multiple system atrophy subtypes by gray matter atrophyJournal Name: Journal of NeuroimagingPublisher: WileyVol: 32Issue #: 1Start Page: 80End Page: 89Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1111/jon.12927Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jon.12927Citation Count: 10
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OPENTitle: Worldwide barriers to genetic testing for movement disordersJournal Name: European Journal of NeurologyPublisher: WileyVol: 28Issue #: 6Start Page: 1901End Page: 1909Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1111/ene.14826Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ene.14826Citation Count: 44
- Focused Workshops2021OPENTitle: Focused WorkshopsJournal Name: European Journal of NeurologyPublisher: WileyVol: 28Issue #: S1Start Page: 23End Page: 43Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1111/ene.14970Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ene.14970Citation Count: 0
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OPENTitle: Effects of exergaming on hippocampal volume and brain‐derived neurotrophic factor levels in Parkinson’s diseaseJournal Name: European Journal of NeurologyPublisher: WileyVol: 29Issue #: 2Start Page: 441End Page: 449Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1111/ene.15165Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ene.15165Citation Count: 42
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OPENTitle: European Academy of Neurology/Movement Disorder Society ‐ European Section guideline on the treatment of Parkinson's disease: I. Invasive therapiesJournal Name: European Journal of NeurologyPublisher: WileyVol: 29Issue #: 9Start Page: 2580End Page: 2595Publication Date:Open Access(OA) Status: OPENLicense: other-oaDOI - Digital Object Identifier: 10.1111/ene.15386Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ene.15386Citation Count: 106
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OPENTitle: Concerns about the European Academy's Recommendations and Guidelines Regarding Pallidotomy for Parkinson's DiseaseJournal Name: European Journal of NeurologyPublisher: WileyVol: 30Issue #: 6Start Page: 1831End Page: 1833Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1111/ene.15569Best OA location URL: https://doi.org/10.1111/ene.15569Citation Count: 5
- Symposia2022OPENTitle: SymposiaJournal Name: European Journal of NeurologyPublisher: WileyVol: 29Issue #: S1Start Page: 6End Page: 19Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1111/ene.15461Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ene.15461Citation Count: 4
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OPENTitle: Novel mutation in MAPT exon 13 (p.N410H) causes corticobasal degenerationJournal Name: Acta NeuropathologicaPublisher: Springer Science and Business Media LLCVol: 127Issue #: 2Start Page: 271End Page: 282Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/s00401-013-1193-7Best OA location URL: http://doi.org/10.1007/s00401-013-1193-7Citation Count: 82
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OPENTitle: Dietary Iron Intake and Risk of Parkinson's DiseaseJournal Name: American Journal of EpidemiologyPublisher: Oxford University Press (OUP)Vol: 168Issue #: 12Start Page: 1381End Page: 1388Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1093/aje/kwn273Best OA location URL: https://academic.oup.com/aje/article-pdf/168/12/1381/365552/kwn273.pdfCitation Count: 93
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OPENTitle: LRRK2 G2019S in Families with Parkinson Disease Who Originated from Europe and the Middle East: Evidence of Two Distinct Founding Events Beginning Two Millennia AgoJournal Name: The American Journal of Human GeneticsPublisher: Elsevier BVVol: 79Issue #: 4Start Page: 752End Page: 758Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1086/508025Best OA location URL: http://www.cell.com/article/S0002929707630870/pdfCitation Count: 124
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OPENTitle: Translation Initiator EIF4G1 Mutations in Familial Parkinson DiseaseJournal Name: The American Journal of Human GeneticsPublisher: Elsevier BVVol: 89Issue #: 3Start Page: 398End Page: 406Publication Date:Open Access(OA) Status: OPENLicense: publisher-specific-oaDOI - Digital Object Identifier: 10.1016/j.ajhg.2011.08.009Best OA location URL: http://www.cell.com/article/S0002929711003594/pdfCitation Count: 303
- Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders2010OPENTitle: Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disordersJournal Name: Acta NeuropathologicaPublisher: Springer Science and Business Media LLCVol: 119Issue #: 6Start Page: 689End Page: 702Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/s00401-010-0664-3Citation Count: 899
- Relationships between lewy and tau pathologies in 375 consecutive non‐Alzheimer's olfactory bulbs2018OPENTitle: Relationships between lewy and tau pathologies in 375 consecutive non‐Alzheimer's olfactory bulbsJournal Name: Movement DisordersPublisher: WileyVol: 33Issue #: 2Start Page: 333End Page: 334Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.27250Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/5809191Citation Count: 2
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OPENTitle: Consumption of Dairy Products and Risk of Parkinson's DiseaseJournal Name: American Journal of EpidemiologyPublisher: Oxford University Press (OUP)Vol: 165Issue #: 9Start Page: 998End Page: 1006Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1093/aje/kwk089Best OA location URL: https://academic.oup.com/aje/article-pdf/165/9/998/204475/kwk089.pdfCitation Count: 191
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OPENTitle: Clinicopathologic discrepancies in a population‐based incidence study of parkinsonism in olmsted county: 1991‐2010Journal Name: Movement DisordersPublisher: WileyVol: 32Issue #: 10Start Page: 1439End Page: 1446Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.27125Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/5931206Citation Count: 28
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OPENTitle: Ser(P)‐1292 LRRK2 in urinary exosomes is elevated in idiopathic Parkinson's diseaseJournal Name: Movement DisordersPublisher: WileyVol: 31Issue #: 10Start Page: 1543End Page: 1550Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.26686Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/5053851Citation Count: 210
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OPENTitle: TDP-43 deposition in prospectively followed, cognitively normal elderly individuals: correlation with argyrophilic grains but not other concomitant pathologiesJournal Name: Acta NeuropathologicaPublisher: Springer Science and Business Media LLCVol: 126Issue #: 1Start Page: 51End Page: 57Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/s00401-013-1110-0Best OA location URL: http://doi.org/10.1007/s00401-013-1110-0Citation Count: 102
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OPENTitle: The MAPT H1 haplotype is associated with tangle-predominant dementiaJournal Name: Acta NeuropathologicaPublisher: Springer Science and Business Media LLCVol: 124Issue #: 5Start Page: 693End Page: 704Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/s00401-012-1017-1Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3608475Citation Count: 82
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OPENTitle: Evaluation of α-synuclein immunohistochemical methods used by invited expertsJournal Name: Acta NeuropathologicaPublisher: Springer Science and Business Media LLCVol: 116Issue #: 3Start Page: 277End Page: 288Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/s00401-008-0409-8Best OA location URL: http://doi.org/10.1007/s00401-008-0409-8Citation Count: 180
- Vagally mediated effects of brain stem dopamine on gastric tone and phasic contractions of the rat2017OPENTitle: Vagally mediated effects of brain stem dopamine on gastric tone and phasic contractions of the ratJournal Name: American Journal of Physiology-Gastrointestinal and Liver PhysiologyPublisher: American Physiological SocietyVol: 313Issue #: 5Start Page: G434End Page: G441Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1152/ajpgi.00180.2017Best OA location URL: https://www.physiology.org/doi/pdf/10.1152/ajpgi.00180.2017Citation Count: 25
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OPENTitle: Are there differences in cerebral white matter lesion burdens between Parkinson’s disease patients with or without dementia?Journal Name: Acta NeuropathologicaPublisher: Springer Science and Business Media LLCVol: 119Issue #: 1Start Page: 147End Page: 149Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/s00401-009-0620-2Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/2928051Citation Count: 44
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OPENTitle: Parkinson’s disease is not associated with gastrointestinal myenteric ganglion neuron lossJournal Name: Acta NeuropathologicaPublisher: Springer Science and Business Media LLCVol: 124Issue #: 5Start Page: 665End Page: 680Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/s00401-012-1040-2Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3473167Citation Count: 195
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OPENTitle: Tremor severity and age: A cross‐sectional, population‐based study of 2,524 young and midlife normal adultsJournal Name: Movement DisordersPublisher: WileyVol: 26Issue #: 8Start Page: 1515End Page: 1520Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.23674Best OA location URL: http://doi.org/10.1002/mds.23674Citation Count: 13
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OPENTitle: Pedestrian safety in patients with Parkinson's disease: A case‐control studyJournal Name: Movement DisordersPublisher: WileyVol: 32Issue #: 12Start Page: 1748End Page: 1755Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.27124Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/5732050Citation Count: 9
- Nonmotor symptoms in healthy Ashkenazi Jewish carriers of the G2019S mutation in the LRRK2 gene2015OPENTitle: Nonmotor symptoms in healthy Ashkenazi Jewish carriers of the G2019S mutation in the LRRK2 geneJournal Name: Movement DisordersPublisher: WileyVol: 30Issue #: 7Start Page: 981End Page: 986Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.26213Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/4478229Citation Count: 67
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OPENTitle: Genetic influences on cognition in progressive supranuclear palsyJournal Name: Movement DisordersPublisher: WileyVol: 32Issue #: 12Start Page: 1764End Page: 1771Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.27196Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/5818145Citation Count: 10
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OPENTitle: Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunctionJournal Name: Acta NeuropathologicaPublisher: Springer Science and Business Media LLCVol: 117Issue #: 6Start Page: 613End Page: 634Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/s00401-009-0538-8Best OA location URL: http://doi.org/10.1007/s00401-009-0538-8Citation Count: 700