The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Outcome Measures, 2021Protective Effect of Immune Gene Subtype in Parkinson’s Disease
Study Rationale: Our genetic studies of Parkinson’s disease (PD) have found a protective effect of an immune gene called HLA-DR, specifically the presence of the HLA-DRB1*04 subtype. We found that HLA...
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Research Grant, 2021Development of Selective PET Imaging Agents for Alpha-synuclein and Tau
Study Rationale: The ability to detect and monitor the accumulation of tau and alpha-synuclein aggregates in the brain is crucial to better understanding the pathophysiology of Progressive...
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Therapeutic Pipeline Program, 2021Compounds that Enhance the Activity of GCase as a Treatment for Parkinson’s Disease
Study Rationale:
Beta-glucocerebrosidase (GCase), a protein that processes some of the key components of cell membranes, is required for normal brain function. Reduced activity of this protein... -
Analysis of Patient-Reported Outcomes from Fox Insight, 2021Characterizing Impairment Trajectories in People with Parkinson’s Disease
Study Rationale:
Little is known about what causes individuals with Parkinson’s disease (PD) to develop symptoms, much less the genetic and non-genetic factors that influence these changes. In most... -
Analysis of Patient-Reported Outcomes from Fox Insight, 2021Exploring Environmental and Genetic Mediators of Progression in Parkinson’s Disease
Study Rationale:
We currently do not understand why some people with Parkinson’s disease (PD) have particularly severe symptoms, or symptoms that progress rapidly, compared to those who do not. This... -
Therapeutic Pipeline Program, 2021Targeting Brain-specific Stearoyl-CoA-Desaturase 5 (SCD5) as a Treatment for Parkinson’s Disease
Study Rationale:
Previous studies have shown that fat molecules called unsaturated fatty acids regulate the harmful effects that alpha-synuclein have on neurons. This protein forms a key part of Lewy...
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Our funding programs support basic, translational and clinical research from academia and industry.