The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Target Advancement Program, 2022Targeting GPR43 in T-cells as a Potential Treatment for Parkinson’s Disease
Study Rationale: Parkinson's disease involves the generation of pathogenic proteins in the neurons, which trigger an immune response driven by inflammatory lymphocytes that infiltrate the brain and...
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Accelerating Early Proof-of-Concept Testing of Promising PD Therapies, 2022Validation of RRx-001 as a Novel Disease-modifying Therapeutic for Parkinson's Disease
Study Rationale: Our project will test the effectiveness of a new treatment for Parkinson’s disease (PD) called RRx-001. We believe this drug could be beneficial in PD by blocking inflammasome...
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Therapeutic Pipeline Program, 2022Developing an Assay to Identify Glucocerebrosidase-enhancing Chaperones for the Treatment of Parkinson’s Disease
Study Rationale: Discovering genes associated with Parkinson’s disease (PD) facilitates the design of new treatment strategies for this disorder. Mutations in the glucocerebrosidase gene (GBA1) are...
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Cellular Phenotyping in Human iPSCS from the PPMI Cohort, 2022Simultaneous Profiling of Gene Expression Patterns from Pooled Cell Samples of Large Parkinson’s Disease Cohorts
Study Rationale: The PPMI study provides a repository of stem cells that can be converted into dopamine-producing neurons and microglia for modeling Parkinson’s disease (PD). Maintaining these cells...
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Research Grant, 2022(Supplement) Self-reported Perceptions and Self-reported Outcomes on Motor and Non-motor Symptoms in the Parkinson's Disease Continuum: A Systematic Review of Mixed Methods
Study Rationale: People are unique in the way they experience quality of life. Throughout the progression of Parkinson's Disease, patients and their care partners have different perceptions of motor...
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Expanding Biological Understanding of Parkinson's Disease, 2022Gaining Mechanistic Insights into PINK1 Genetic Variants
Study Rationale: Mutations in the Parkin and PINK1 genes cause early-onset familial Parkinson's disease (PD). These genes produce enzymes that function together to degrade damaged mitochondria, the...
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Our funding programs support basic, translational and clinical research from academia and industry.