The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Therapeutic Pipeline Program, 2019Small Molecule Therapeutics Targeting Nurr1
Study Rationale:
Nurr1 is a protein that plays critical roles in the development, maintenance and survival of dopaminergic neurons and, as such, is a potential therapeutic target for treating the... -
Therapeutic Pipeline Program, 2019Development of a Novel TRPML1 Activator for Parkinson’s Disease
Study Rationale:
A primary cause of Parkinson’s disease is build-up of a toxic protein in specific neurons in the brain. There is evidence that in Parkinson’s disease the cellular machinery to clear... -
Epidemiological Parkinson's Risk Modifiers, 2019Association of Dietary Patterns with Parkinson’s Symptoms and Pathology
Study Rationale:
Currently there is no preventive treatment for Parkinson’s disease. Our recent analyses has indicated that healthy dietary patterns such as the MIND (Mediterranean-DASH Intervention... -
Research Grant, 2019Inhibition of LRRK2 Roc-COR GTPase
Study Rationale:
The LRRK2 protein is overactive in people with Parkinson’s and a mutation in the LRRK2 gene. Recent research shows LRRK2 may be overactive in a sporadic (cause unknown) Parkinson’s... -
Therapeutic Pipeline Program, 2019Managing Levodopa-induced Dyskinesias by Targeting Dopamine D1 Receptor Signaling
Study Rationale:
Parkinson’s is a complex brain disease caused by the gradual loss of brain cells producing the neurotransmitter dopamine, which controls movement, emotion and affect. However... -
Research Grant, 2019Tool to Identify Parkinson’s Disease Using Digital Facial Expression Biomarkers
Study Rationale:
Traditional Parkinson’s disease (PD) detection and monitoring systems lack objective biomarkers and are often reliant on late-stage symptoms. By contrast, a masked face is often seen...
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Our funding programs support basic, translational and clinical research from academia and industry.