The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Translational Pipeline Program, 2023Using Sleep Modulation to Enhance the Brain’s Waste Clearance Mechanisms as an Approach to Limiting the Progression of Parkinson’s Disease
Study Rationale: Recent studies have demonstrated that the brains of people with Parkinson’s disease (PD) show a buildup of toxic proteins that is due to an impairment in the brain’s waste clearance...
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Research Grant, 2023Enhancing Access to Meaningful Data: Nebraska Parkinson’s Disease Registry
Study Rationale: Nebraska’s Parkinson’s Disease Registry (NPDR) will roll out a new electronic data collection system, enforce state statutes requiring that physicians participate in reporting...
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Translational Pipeline Program, 2023Exploring the Use of Molecules that Stabilize the Interaction between LRRK2 Kinase and the 14-3-3 Adapter Protein as a Neuroprotective Therapy for Parkinson’s Disease
Study Rationale: Parkinson’s disease (PD) is associated with activating mutations in a protein kinase called LRRK2. In previous studies, we found that regulating LRRK2’s chemical modification by...
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Parkinson’s Pathway Molecular Data Analysis Program, 2022Assessment of Proinflammatory Cytokines as Biomarkers for Parkinson’s Disease
Study Rationale: We have generated a computer-based model that simulates alterations in molecular mechanisms associated with Parkinson’s disease (PD) genes. This model suggested that, in sporadic...
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Parkinson’s Pathway Molecular Data Analysis Program, 2022Interaction of Mitochondrial Genes and Lifestyle Factors on Age at Onset in Parkinson’s Disease
Study Rationale: Cellular structures called mitochondria are functionally impaired in Parkinson’s disease (PD). How environmental toxins or lifestyle factors influence mitochondrial function and...
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Parkinson’s Pathway Molecular Data Analysis Program, 2022Developing Biomarker Signatures of Parkinson’s Disease Using a Novel Progression Model
Study Rationale: Although Parkinson’s disease (PD) affects individuals differently, there are groups of people with PD who share similar features and whose disease changes similarly over time...
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Our funding programs support basic, translational and clinical research from academia and industry.