Title:Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes
Author(s):Yann Le Guen, Guo Luo, Aditya Ambati, Vincent Damotte, Iris E. Jansen, Eric Yu, Aude Nicolas, Itziar de Rojas, Thiago Peixoto Leal, Akinori Miyashita, Céline Bellenguez, Michelle Mulan Lian, Kayenat Parveen, Takashi Morizono, Hyeonseul Park, Benjamin Grenier‐Boley, Tatsuhiko Naito, Fahri Küçükali, Seth D. Talyansky, Selina Yogeshwar, Vicente Peris Sempere, Wataru Satake, Victoria Álvarez, Beatrice Arosio, Michaël E. Belloy, Luisa Benussi, Anne Boland, Barbara Borroni, María J. Bullido, Paolo Caffarra, Jordi Clarimón, Antonio Daniele, D.H. Darling, Stéphanie Debette, Jean‐François Deleuze, Martin Dichgans, Carole Dufouil, Emmanuel During, Emrah Düzel, Daniela Galimberti, Guillermo García‐Ribas, José María García‐Alberca, Pablo García‐González, Vilmantas Giedraitis, Oliver Goldhardt, Caroline Graff, Edna Grünblatt, Olivier Hanon, Lucrezia Hausner, Stefanie Heilmann‐Heimbach, Henne Holstege, Jakub Hort, Yoo Jin Jung, Jürgen Deckert, Silke Kern, Teemu Kuulasmaa, Kun Ho Lee, Ling Lin, Carlo Masullo, Patrizia Mecocci, Shima Mehrabian, Alexandre de Mendonça, Merçé Boada, Pablo Mir, Susanne Moebus, Fermín Moreno, Benedetta Nacmias, Gaël Nicolas, Shumpei Niida, Børge G. Nordestgaard, Goran Papenberg, Janne M. Papma, Lucilla Parnetti, Florence Pasquier, Pau Pástor, Oliver Peters, Yolande A.L. Pijnenburg, Gerard Piñol‐Ripoll, Julius Popp, Laura Molina‐Porcel, Raquel Puerta, Jordi Pérez‐Tur, Innocenzo Rainero, Inez H.G.B. Ramakers, Luís Miguel Real, Steffi G. Riedel‐Heller, Eloy Rodríguez‐Rodríguez, Owen A. Ross, José Luís Royo, Dan Rujescu, Nikolaos Scarmeas, Philip Scheltens, Norbert Scherbaum, Anja Schneider, Davide Seripa, Ingmar Skoog, Vincenzo Solfrizzi, Gianfranco Spalletta, Alessio Squassina, John C. van Swieten, Raquel Sánchez‐Valle, Eng‐King Tan, Thomas Tegos, Charlotte E. Teunissen, Jesper Qvist Thomassen, Lucio Tremolizzo, Martin Vyhnálek, Frans Verhey, Margda Wærn, Jens Wiltfang, Jing Zhang, Henrik Zetterberg, Kaj Blennow, Zihuai He, Julie Williams, Philippe Amouyel, Frank Jessen, Patrick G. Kehoe, Ole A. Andreassen, Cornelia van Duin, Magda Tsolaki, Pascual Sánchez‐Juan, Ruth Frikke‐Schmidt, Kristel Sleegers, Tatsushi Toda, Anna Zettergren, Martin Ingelsson, Yukinori Okada, Giacomina Rossi, Mikko Hiltunen, Jungsoo Gim, Kouichi Ozaki, Rebecca Sims, Jia Nee Foo, Wiesje M. van der Flier, Takeshi Ikeuchi, Alfredo Ramı́rez, Ignácio F. Mata, Agustı́n Ruiz, Ziv Gan‐Or, Jean‐Charles Lambert, Michael D. Greicius, Emmanuel Mignot, Céline Bellenguez, Fahri Küçükali, Iris E. Jansen, Víctor Andrade, Sonia Moreno‐Grau, Najaf Amin, Benjamin Grenier‐Boley, Rafael Campos‐Martin, Peter Holmans, Anne Boland, Luca Kleineidam, Vincent Damotte, Sven J. van der Lee, Teemu Kuulasmaa, Itziar de Rojas, Amber Yaqub, Ivana Nedeljković, Marcos R. Costa, Julien Chapuis, Shahzad Ahmad, Vilmantas Giedraitis, Dag Aarsland, Pablo García‐González, Carla Abdelnour, Emilio Alarcón‐Martín, Daniel Alcolea, Montserrat Alegret, Ignacio Álvarez, Victoria Álvarez, Nicola J. Armstrong, Tsolaki Anthoula, Ildebrando Appollonio, Marina Arcaro, Silvana Archetti, Alfonso Arias Pastor, Beatrice Arosio, Lavinia Athanasiu, Henri Bailly, Nerisa Banaj, Miquel Baquero, Ana Belén Pastor, Luisa Benussi, Claudine Berr, Céline Besse, Valentina Bessi, Giuliano Binetti, Alessandra Bizarro, Rafael Blesa, Merçé Boada, Barbara Borroni, Silvia Boschi, Paola Bossù, Geir Bråthen, Catherine Bresner, Henry Brodaty, Keeley J. Brookes, Luis Ignacio Brusco, Dolores Buiza‐Rueda, Katharina Bürger, Vanessa Burholt, Miguel Calero, Geneviève Chêne, Ãngel Carracedo, Roberta Cecchetti, Laura Cervera‐Carles, Camille Charbonnier, Caterina Chillotti, Simona Ciccone, Jurgen A.H.R. Claassen, Jordi Clarimón, Christopher Clark, Elisa Conti, Anaïs Corma‐Gómez, Emanuele Maria Costantini, Carlo Custodero, Delphine Daian, Carolina Dalmasso, Antonio Daniele, Efthimios Dardiotis, Jean‐François Dartigues, Peter Paul De Deyn, Stéphanie Debette, Jürgen Deckert, Teodoro del Ser, Nicola Denning, Martin Dichgans, Janine Diehl‐Schmid, Mónica Díez-Fairén, Paolo Rossi, Srdjan Djurovic, Emmanuelle Duron, Emrah Düzel, Carole Dufouil, Valentina Escott‐Price, Ana Espinosa, Michael Ewers, Marta Fernández‐Fuertes, Catarina B. Ferreira, Evelyn Ferri, Bertrand Fin, Peter Fischer, Tormod Fladby, Klaus Fließbach, Juan Fortea, Silvia Fostinelli, Nick C. Fox, Emlio Franco-Macías, María J. Bullido, Ana Frank, Lutz Froelich, Daniela Galimberti, José María García‐Alberca, Pablo García‐González, Sebastián García‐Madrona, Guillermo García‐Ribas, Roberta Ghidoni, Ina Giegling, Giaccone Giorgio, Oliver Goldhardt, Antonio González-Pérez, Caroline Graff, Giulia Grande, Emma Green, Timo Grimmer, Edna Grünblatt, Tamar Guetta-Baranés, Annakaisa Haapasalo, Georgios M. Hadjigeorgiou, Harald Hampel, Olivier Hanon, John Hardy, Annette M. Hartmann, Lucrezia Hausner, Janet Harwood, Stefanie Heilmann‐Heimbach, Seppo Helisalmi, Michael T. Heneka, Isabel de la Torre Díez, Martin J. Herrmann, Per Hoffmann, Clive Holmes, Henne Holstege, Raquel Huerto Vilas, Marc Hulsman, Charlotte Johansson, Lena Kilander, Anne Kinhult Ståhlbom, Miia Kivipelto, Anne M. Koivisto, Johannes Kornhuber, Mary H. Kosmidis, Carmen Lage, Erika J. Laukka, Alessandra Lauria, Jenni Lehtisalo, Ondřej Lerch, Alberto Lleó, Adolfo López de Munain, Malin Löwemark, Lauren Luckcuck, Juan Macı́as, Catherine Macleod, Wolfgang Maier, Francesca Mangialasche, Spallazzi Marco, Marta Marquié, Iain Marshall, Ángel Martín Montes, Carmen Martínez Rodríguez, Carlo Masullo, Simon Mead, Patrizia Mecocci, Miguel Medina, Alun Meggy, Shima Mehrabian, Silvia Mendoza, Manuel Menéndez‐González, Pablo Mir, Susanne Moebus, Merel O. Mol, Laura Molina‐Porcel, Laura Montrreal, Laura Morelli, Fermín Moreno, Kevin Morgan, Markus M. Möthen, Carolina Muchnik, Benedetta Nacmias, Tiia Ngandu, Gaël Nicolas, Børge G. Nordestgaard, Robert Olaso, Adelina Orellana, Michela Orsini, Gemma Ortega, Alessandro Padovani, Paolo Caffarra, Goran Papenberg, Lucilla Parnetti, Pau Pástor, Alba Pérez‐Cordón, Jordi Pérez‐Tur, Pierre Péricard, Oliver Peters, Yolande A.L. Pijnenburg, Juan A. Pineda, Gerard Piñol‐Ripoll, Claudia Pisanu, Thomas Polak, Julius Popp, Daniëlle Posthuma, Josef Priller, Raquel Puerta, Olivier Quenez, Inés Quintela, Jesper Qvist Thomassen, Alberto Rábano, Innocenzo Rainero, Inez Ramakers, Luís Miguel Real, Marcel J. T. Reinders, Steffi G. Riedel‐Heller, Peter Riederer, Natalia Roberto, Eloy Rodríguez‐Rodríguez, Arvid Rongve, Irene Rosas Allende, Maiteé Rosende‐Roca, José Luís Royo, Elisa Rubino, Dan Rujescu, María Eugenia Sáez, Paraskevi Sakka, Ingvild Saltvedt, Ángela Sanabria, María Bernal Sánchez-Arjona, Florentino Sánchez-García, Pascual Sánchez‐Juan, Raquel Sánchez‐Valle, Sigrid Botne Sando, Michela Scamosci, Nikolaos Scarmeas, Elio Scarpini, Philip Scheltens, Norbert Scherbaum, Martin Scherer, Matthias Schmid, Anja Schneider, Jonathan M. Schott, Geir Selbæk, Davide Seripa, Alexey Shadrin, Olivia Anna Skrobot, Hilkka Soininen, Vincenzo Solfrizzi, Alina Solomon, Sandro Sorbi, Óscar Sotolongo‐Grau, Gianfranco Spalletta, Annika Spottke, Alessio Squassina, Eystein Stordal, Juan Pablo Tartan, Lluís Tárraga, Niccoló Tesi, Anbupalam Thalamuthu, Thomas Tegos, Latchezar Traykov, Lucio Tremolizzo, Anne Tybjærg‐Hansen, André G. Uitterlinden, Abbe Ullgren, Ingun Ulstein, Sergi Valero, Aad van der Lugt, Jasper Van Dongen, Jeroen van Rooij, John C. van Swieten, Rik Vandenberghe, Frans Verhey, Jean‐Sébastien Vidal, Jonathan Vogelgsang, Martin Vyhnálek, Michael Wagner, David Wallon, Leonie Weinhold, Jens Wiltfang, Gill Windle, Bob Woods, Mary Yannakoulia, Miren Zulaica, Jan Laczó, Václav Maťoška, María Serpente, Francesca Assogna, Fabrizio Piras, Fabrizio Piras, Valentina Ciullo, Jacob Shofany, Carlo Ferrarese, Simona Andreoni, Gessica Sala, C Zoia, Maria Del Zompo, Alberto Benussi, Patrizia Bastiani, Mari Takalo, Teemu Natunen, Tiina Laatikainen, Jaakko Tuomilehto, Riitta Antikaínen, Timo Strandberg, Jaana Lindström, Markku Peltonen, Richard Abraham, Ammar Al‐Chalabi, Nicholas Bass, Carol Brayne, Kristelle S. Brown, John Collinge, David W. Craig, Pangiotis Deloukas, Nick C. Fox, Amy Gerrish, Michael Gill, Rhian Gwilliam, John Hardy, Denise Harold, Paul Hollingworth, Jarret A. Johnston, Lesley Jones, Brian Lawlor, Gill Livingston, Simon Lovestone, Michelle K. Lupton, Aoibhinn Lynch, David Mann, Bernadette McGuinness, Andrew McQuillin, Michael O’Donovan, Michael J. Owen, Peter Passmore, John Powell, Petroula Proitsi, Martin N. Rossor, Christopher E. Shaw, A. David Smith, Hugh Gurling, Stephen Todd, Catherine J. Mummery, Nathalie Ryan, Giordano Lacidogna, Ad Adarmes-Gómez, Ana Mauleón, Ana Pancho, A. Gailhajenet, Asunción Lafuente, Daniel Macías‐García, Elvira Martín, Esther Pelejà, F. Carrillo, Isabel Sastre Merlín, L. Garrote-Espina, Liliana Vargas, Mario Carrión‐Claro, María Esmeralda Arreola Marín, Ma Labrador, Mar Buendía, M. D. Alonso, Marina Guitart, Mariona Moreno, Marta Ibarria, Mt Periñán, Núria Aguilera, Pilar Gómez‐Garre, Pilar Cañabate, R. Escuela, R. Pineda-Sanchez, R. Vigo-Ortega, Silvia Jesús, Sílvia Preckler, Silvia Rodrigo‐Herrero, Susana Diego, Alessandro Vacca, Fausto Roveta, Nicola Salvadori, Elena Chipi, Henning Boecker, Christoph Laske, Robert Perneczky, Costas A. Anastasiou, Daniel Janowitz, Rainer Malik, Anna Anastasiou, Kayenat Parveen, Carmen Lage, Sara López‐García, Anna Antonell, Kalina Mihova, Diyana Belezhanska, Heike Weber, Silvia Kochen, Patricia Solís, Nancy Medel, Julieta Lisso, Zulma Sevillano, Daniel Gustavo Politis, Valeria Cores, Carolina Cuesta, Cecilia Ortíz, Juan Ignacio Bacha, Mario Rios, Aldo Saenz, Mariana Sanchez Abalos, Eduardo Köhler, Dana Lis Palacio, Ignacio Etchepareborda, Matias Köhler, Gisela V. Novack, Federico Ariel Prestia, Pablo Galeano, Eduardo M. Castaño, Sandra Germani, Carlos Reyes Toso, Matias Rojo, Carlos A. Ingino, Carlos A. Mangone, Sebastiaan Engelborghs, Fabrizio Tagliavini, Yan V. Sun, Lucia Farotti, Chiara Fenoglio, Geert Jan Biessels, Seth Love, Patrick G. Kehoe, Florence Pasquier, Christine Van Broeckhoven, David C. Rubinsztein, Stefan Teipel, Nathalie Fiévet, Vincent Deramecourt, Charlotte Forsell, Håkan Thonberg, Maria Bjerke, Ellen De Roeck, Nicholas G. Martin, Natividad Olivar, Mohsen Ghanbari, Perminder S. Sachdev, Karen A. Mather, Frank Jessen, M. Arfan Ikram, Alexandre de Mendonça, Jakub Hort, Tsolaki Magda, Philippe Amouyel, Julie Williams, Ruth Frikke‐Schmidt, Jordi Clarimón, Jean‐François Deleuze, Giacomina Rossi, Ole A. Andreassen, Martin Ingelsson, Mikko Hiltunen, Kristel Sleegers, Cornelia M. van Duijn, Rebecca Sims, Wiesje M. van der Flier, Agustı́n Ruiz, Alfredo Ramı́rez, Jean‐Charles Lambert, N. Aguilera, Estefanía Burgos Alarcón, Montserrat Alegret, Merçé Boada, Marie‐Annick Buendia, Amanda Cano, Pilar Cañabate, Ãngel Carracedo, Arturo Corbatón Anchuelo, Itziar de Rojas, S. Diego, Ana Espinosa, A. Gailhajenet, Pablo García‐González, M. Guitart, A González-Péerez, Marta Ibarria, A. Lafuente, Juan Macı́as, Olalla Maroñas, Elisabeth Martin, M.T.M. Martinez, Marta Marquié, Laura Montrreal, Sonia Moreno‐Grau, M. Moreno, Raúl Núñez‐Llaves, C. Olivé, Adelina Orellana, Gemma Ortega, Ana Pancho, E. Pelejà, Alba Pérez‐Cordón, Juan A. Pineda, R. de la Puerta, Sílvia Preckler, Inés Quintela, Luís Miguel Real, Maiteé Rosende‐Roca, Agustı́n Ruiz, ME Sáez, Ángela Sanabria, Manuel Serrano‐Ríos, Óscar Sotolongo‐Grau, L Táarraga, Sergi Valero, Liliana Vargas, Ad Adarmes-Gómez, Emilio Alarcón‐Martín, MD Alonso, Ignacio Álvarez, Victoria Álvarez, G. Amer-Ferrer, M. Antequera, Carmen Antúnez, Miquel Baquero, M. Bernal, Rafael Blesa, Merçé Boada, Dolores Buiza‐Rueda, MJ Bullido, Burguera Ja, Miguel Calero, F. Carrillo, Mario Carrión‐Claro, MJ Casajeros, Jordi Clarimón, JM Cruz-Gamero, Marian M. de Pancorbo, Itziar de Rojas, Teodoro del Ser, Mónica Díez-Fairén, R. Escuela, L. Garrote-Espina, Juan Fortea, Emilio Franco, Ana Frank, JM García-Alberca, S. García Madrona, Guillermo García‐Ribas, Pilar Gómez‐Garre, S. Hevilla, Silvia Jesús, MA Labrador Espinosa, Carmen Lage, A. Legaz, A Lleóo, A Lóopez de Munáin, Sara López‐García, Daniel Macías‐García, Salvadora Manzanares, María Esmeralda Arreola Marín, Juan Marín-Muñoz, T Marín, Marta Marquié, Ángel Martín Montes, B. Martínez, Carmen Martı́nez, Vicente Martı́nez, A Martínez-Lage Álvarez, Miguel Medina, Maite Mendióroz, Manuel Menéndez‐González, Pablo Mir, Laura Montrreal, Adelina Orellana, Pau Pástor, J Péerez Tur, María Teresa Periñán, R. Pineda-Sanchez, G. Piñol Ripoll, A Ráabano, Diego Real de Asúa, S. Rodrigo, Eloy Rodríguez‐Rodríguez, JL Royo, Agustı́n Ruiz, R. Sanchez del Valle Díaz, Pascual Sánchez‐Juan, Isabel Sastre, Óscar Sotolongo‐Grau, Sergi Valero, MP Vicente, R. Vigo-Ortega, L. Vivancos, Alexey Shadrin, Shahram Bahrami, Arvid Rongve, Geir Bråthen, Ingunn Bosnes, Eystein Stordal, Lavinia Athanasiu, Per Selnes, Ingvild Saltvedt, Sigrid Botne Sando, Sverre Bergh, Ingun Ulstein, Srdjan Djurovic, Tormod Fladby, Dag Aarsland, Geir Selbæk, Ole A. Andreassen, Céline Bellenguez, Benjamin Grenier‐Boley, Jacques Epelbaum, David Wallon, Didier Hannequin, Florence Pasquier, Claudine Berr, Jean‐François Dartigues, Dominique Campion, Christophe Tzourio, Vincent Dermecourt, Nathalie Fiévet, Olivier Hanon, Carole Dufouil, Alexis Brice, Bruno Dubois, Karen Ritchie, Philippe Amouyel, Jean‐Charles Lambert, Denise Harold, Paul Hollingworth, Rebecca Sims, Amy Gerrish, Nicola Denning, Amy L. Williams, Charlene Thomas, Alun Meggy, Iain Marshall, Chloe Davies, Lauren Luckcuck, Will Nash, Kimberley Dowzell, Atahualpa Castillo-Morales, Mateus Bernardo-Harrington, Patrick G. Kehoe, Per Hoffmann, Seth Love, James Turton, Jenny Lord, Kristelle Brown, Kevin Morgan, Emma Vardy, Elizabeth Fisher, Jason D. Warren, Jonathan M. Schott, Martin N. Rossor, Natalie S. Ryan, Nick C. Fox, Rita Guerreiro, Simon Mead, James Uphill, John Collinge, Michelle K. Lupton, Ammar Al‐Chalabi, Christopher E. Shaw, Nicholas Bass, Richard Abraham, Reinhard Heun, Heike Kölsch, Britta Schürmann, Frank Jessen, Wolfgang Maier, ndré Lacour, Christine Herold, Simon Lovestone, Bernadette McGuinness, David W. Craig, Janet Johnston, Michael Gill, Peter Passmore, Stephen Todd, John Powell, Petroula Proitsi, Yogen Patel, Angela Hodges, Tim Becker, A. David Smith, Donald Warden, Gordon Wilcock, Robert Clarke, Aoibhinn Lynch, Brian Lawlor, Michael Gill, Andrew McQuillin, Gill Livingston, John Hardy, David C. Rubinsztein, Carol Brayne, Rhian Gwilliam, Panos Deloukas, Yoav Ben‐Shlomo, David Mann, Nigel M. Hooper, Stuart Pickering‐Brown, Clive Holmes, Rebecca Sussams, Nicholas A. Warner, Antony Bayer, Andrew B. Singleton, Annette M. Hartmann, Dan Rujescu, Ina Giegling, Harald Hampel, Martin Dichgans, Isabella Heuser, Dmitriy Drichel, Norman Klopp, Markus M. Nöthen, Manuel Mayhaus, Markus J. Riemenschneider, Sabrina Pinchler, Thomas Feulner, Wei Gu, Hendrik den Bussche, Martin Scherer, Jens Wiltfang, Johannes Kornhuber, Michael Hüll, Lutz Frölich, H‐Erich Wichmann, Karl‐Heinz Jöckel, Susanne Moebus, Steffi G. Riedel‐Heller, John Kauwe, John C. Morris, Kevin H. Mayo, Magda Tsolaki, Michael O’Donovan, Lesley Jones, Michael J. Owen, Valentina Escott‐Price, Alfredo Ramı́rez, Peter Holmans, Julie Williams, Jia Nee Foo, Elaine Guo Yan Chew, Sun Ju Chung, Rong Peng, Yinxia Chao, Louis Tan, Moses Tandiono, Michelle Mulan Lian, Ebonne Ng, Kumar‐M. Prakash, Wing‐Lok Au, Wee-Yang Meah, Shi Qi Mok, Azlina Ahmad‐Annuar, Anne Chan, Ling Chen, Yongping Chen, Beom S. Jeon, Lulu Jiang, Jia Lun Lim, Juei‐Jueng Lin, Chun‐Feng Liu, Cheng‐Jie Mao, Vincent Mok, Zhong Pei, Huifang Shang, Changhe Shi, Kyuyoung Song, Ai Huey Tan, Yih‐Ru Wu, Yuming Xu, Renshi Xu, Yaping Yan, Jing Yang, Bao Rong Zhang, Woon‐Puay Koh, Shen‐Yang Lim, Chiea Chuen Khor, Jianjun Liu, Eng‐King Tan
Journal Name:Proceedings of the National Academy of Sciences
Publisher:Proceedings of the National Academy of Sciences
Vol:120
Issue #:36
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Open Access(OA) Status:OPEN
License:cc-by
DOI - Digital Object Identifier:10.1073/pnas.2302720120
Title:Multiomics analysis identifies novel facilitators of human dopaminergic neuron differentiation
Author(s):Borja Gomez Ramos, Jochen Ohnmacht, Nikola de Lange, Elena Valceschini, Aurélien Ginolhac, Marie Catillon, Daniele Ferrante, Aleksandar Raković, Rashi Halder, François Massart, Giuseppe Arena, Paul Antony, Silvia Bolognin, Christine Klein, Roland Krause, Marcel H. Schulz, Thomas Sauter, Rejko Krüger, Lasse Sinkkonen
Journal Name:EMBO Reports
Publisher:Springer Science and Business Media LLC
Vol:25
Issue #:1
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Open Access(OA) Status:OPEN
License:cc-by
DOI - Digital Object Identifier:10.1038/s44319-023-00024-2
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