Title:The effect of LRRK2 loss-of-function variants in humans
Author(s):Nicola Whiffin, Irina M. Armean, Aaron Kleinman, Jamie L. Marshall, Eric Vallabh Minikel, Julia K. Goodrich, Nicholas M. Quaife, Joanne B. Cole, Qingbo Wang, Konrad J. Karczewski, Beryl B. Cummings, Laurent C. Francioli, Kristen M. Laricchia, Anna Guan, Babak Alipanahi, Peter Morrison, Marco A. S. Baptista, Juliana C.N. Chan, Irina M. Armean, Eric Banks, Louis Bergelson, Kristian Cibulskis, Ryan L. Collins, Kristen M. Connolly, Miguel Covarrubias, Beryl B. Cummings, Mark J. Daly, Stacey Donnelly, Yossi Farjoun, Steven Ferriera, Stacey Gabriel, Laura D. Gauthier, Jeff Gentry, Namrata Gupta, Thibault Jeandet, Diane Kaplan, Kristen M. Laricchia, Christopher Llanwarne, Ruchi Munshi, Benjamin M. Neale, Sam Novod, Anne O’Donnell‐Luria, Nikelle Petrillo, Timothy Poterba, David Roazen, Valentín Ruano-Rubio, Andrea Saltzman, Kaitlin E. Samocha, Molly Schleicher, Cotton Seed, Matthew Solomonson, José Soto, Grace Tiao, Kathleen Tibbetts, Charlotte Tolonen, Christopher Vittal, Gordon Wade, Arcturus Wang, Nicholas A. Watts, Ben Weisburd, Carlos A. Aguilar‐Salinas, Tariq Iqbal, Christine M. Albert, Diego Ardissino, Gil Atzmon, John Barnard, Laurent Beaugerie, Emelia J. Benjamin, Michael Boehnke, Lori L. Bonnycastle, Erwin P. Böttinger, Donald W. Bowden, Matthew J. Bown, John C. Chambers, Juliana C.N. Chan, Daniel I. Chasman, Judy H. Cho, Mina K. Chung, Bruce M. Cohen, Adolfo Correa, Dana Dabelea, Dawood Darbar, Ravindranath Duggirala, Josée Dupuis, Patrick T. Ellinor, Roberto Elosúa, Jeanette Erdmann, Martti Färkkilâ, José C. Florez, André Franke, Gad Getz, Benjamin Gläser, Stephen J. Glatt, David Goldstein, Clicerio González, Leif Groop, Christopher Haiman, Craig L. Hanis, Matthew C. Kiernan, Mikko Hiltunen, Matti Holi, Christina M. Hultman, Mikko Kallela, Jaakko Kaprio, Sekar Kathiresan, Olle Melander, Young Jin Kim, George Kirov, Jaspal S. Kooner, Barbara Franke, Harlan M. Krumholz, Subra Kugathasan, Soo Heon Kwak, Markku Laakso, Terho Lehtimäki, Ruth J. F. Loos, Steven A. Lubitz, Ronald C.W., Daniel G. MacArthur, Jaume Marrugat, Kari M. Mattila, Steven A. McCarroll, Mark I. McCarthy, Dermot McGovern, Ruth McPherson, James B. Meigs, Olle Melander, Andres Metspalu, Peter M. Nilsson, Michael O’Donovan, Döst Öngür, Lorena Orozco, Michael J. Owen, Colin N. A. Palmer, Aarno Palotie, Kyong Soo Park, Carlos N. Pato, Ann E. Pulver, Nazneen Rahman, Anne M. Remes, John D. Riou, Samuli Ripatti, Dan M. Roden, Danish Saleheen, Veikko Salomaa, Nilesh J. Samani, Jeremiah M. Scharf, Heribert Schunkert, Moore B. Shoemaker, Pamela Sklar, Hilkka Soininen, Harry Sokol, Tim D. Spector, Patrick F. Sullivan, Jaana Suvisaari, E Shyong Tai, Yik Ying Teo, Jaakko Tuomilehto, Ming T. Tsuang, Dan Turner, Teresa Tusié‐Luna, Erkki Vartiainen, Marquis P. Vawter, James S. Ware, Hugh Watkins, Rinse K. Weersma, Maija Wessman, James S. Pankow, Ramnik J. Xavier, James S. Ware, Aki S. Havulinna, Bozenna Iliadou, Jung‐Jin Lee, Girish N. Nadkarni, Cole Whiteman, Michelle Agee, Adam Auton, Lavínia Schüler Faccini, Scott D. Gordon, Benjamin Elsworth, Pierre Fontanillas, Nicholas A. Furlotte, Barry Hicks, David A. Hinds, Nicholas J. Timpson, Ethan M. Jewett, Yunxuan Jiang, Keng‐Han Lin, Nadia K. Litterman, Matthew H. McIntyre, Kimberly F. McManus, Joanna L. Mountain, Jin Li, Carrie A. M. Northover, Steven J. Pitts, G. David Poznik, J. Fah Sathirapongsasuti, Janie F. Shelton, Suyash Shringarpure, Chao Tian, Andrés Ruiz‐Linares, Vladimir Vacic, Xin Wang, Catherine H. Wilson, Mark J. Daly, Tõnu Esko, Christina M. Hultman, Ruth J. F. Loos, Lili Milani, Aarno Palotie, Carlos N. Pato, Michele T. Pato, Danish Saleheen, Patrick F. Sullivan, Jessica Alföldi, Paul J. Cannon, Daniel G. MacArthur
Journal Name:Nature Medicine
Publisher:Springer Science and Business Media LLC
Vol:26
Issue #:6
Start Page:869
End Page:877
Publication Date:
Open Access(OA) Status:OPEN
License:cc-by, cc-by
DOI - Digital Object Identifier:10.1038/s41591-020-0893-5